"With antibiotic resistance, we've seen this problem grow very slowly over the past century, and it's an enormous threat," says Laurel
Legenza, an assistant scientist and interim director of global health at the UW-Madison School of Pharmacy, who led the work. "We know
there's an opportunity to improve by selecting an antibiotic that considers the local antibiotic resistance trend. And that's really the heart of
the project, is to provide data in a visualization that would improve its use and application directly to patient care."

The research team analyzed 202 antibiograms - tables of antibiotic resistance - from Wisconsin hospitals collected between 2009 and
2015, which documented the susceptibility of 200,000 strains of the pathogenic bacterium Escherichia coli to seven classes or
combinations of drugs. Plotted on a map of the state, the data created discrete points that then had to be stitched together to produce
broad regions of antibiotic susceptibility using cartographic methods contributed by the State Cartographer's Office.

"It's incredible what two disciplines can do together that otherwise they wouldn't do on their own," Legenza says of the collaboration
between pharmacists and cartographers.

View the Maps and READ MORE AT https://news.wisc.edu/antibiotic-resistance-across-wisconsin-revealed-by-new-maps/

ANTIBIOTIC RESISTANCE ACROSS WISCONSIN REVEALED BY
NEW MAPS
From UW-Madison
MADISON - When a patient arrives at a hospital with an infection, her doctor must decide
which antibiotic might have the best chance of curing her - no easy feat when disease-
causing pathogens are increasingly resistant to multiple antibiotics.

For that reason, hospitals often track the antibiotic resistance profiles of infectious
microbes that they isolate from sick patients, which provide information on the most and
least effective drugs. But that data is often isolated to a particular hospital and may be
difficult to access or hard to interpret, leaving physicians in the dark about which drug is
ideal for their patients.

To make this data more accessible, a team of researchers at the University of Wisconsin-
Madison School of Pharmacy and the State Cartographer's Office have developed a
prototype system that maps out trends in antibiotic resistance across Wisconsin. They
drew inspiration from easy-to-read weather maps and consulted with doctors to develop
the tool, which provides guidance at a glance of the likelihood a pathogen will respond to a
particular drug.

Having now created a proof-of-concept visualization, the researchers are pursuing finer-
grained location data while partnering with hospitals to determine how their new tool,
named AMR Tracker, can be incorporated into physician workflows in the future. The
researchers published their work online April 1 in the journal Antimicrobial Agents and
Chemotherapy.